difficile infection, and the sequences of each sample were compared with those of healthy individuals who were a part of the Human Microbiome Project. The samples were also compared with those of 10 other patients with recurrent C. Each pre- and post-FMT sample was compared. The composition of bacteria in each fecal sample was assessed using high-throughout genome sequencing. The researchers collected fecal samples from the patients both before FMT and daily for up to 151 days after the procedure. difficile infection to their study, all of whom were scheduled for FMT after treatment with antibiotics failed. To find out, the team enrolled four patients with recurrent C. Patients’ gut bacteria remained healthy for up to 21 weeks after FMT However, Sadowsky and colleagues note that, while past studies have shown that the fecal microbiota of FMT patients is similar to that of the donor, it is unclear as to whether the changes in gut bacteria as a result of FMT are long lasting. It is believed to work by replacing the “friendly” gut bacteria that has been wiped out through overpopulation of C. In these cases, fecal microbiota transplantation (FMT) may be recommended.įMT involves collecting the fecal matter of a healthy donor, before purifying it and placing it into the recipients’ gut – most commonly via colonoscopy. difficile infections can be treated with antibiotics, the infection can keep coming back for some patients. Infection with the bacterium causes colon inflammation, known as colitis, which can lead to fever, loss of appetite, nausea, diarrhea and abdominal pain. Infection with the bacterium can occur through contact with surfaces or items contaminated with feces. According to the Centers for Disease Control and Prevention (CDC), the bacterium caused around half a million infections in 2011 and killed around 29,000 people within 30 days of diagnosis.Ĭ. difficile infections are a major health concern in the US. Study co-author Michael Sadowsky, of the Microbial and Plant Genomics Institute at the University of Minnesota, and colleagues publish their findings in the journal Microbiome.Ĭ.
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